brain tumors: Microwave News Article Archive (2004 - )

A system to treat brain cancer with 100-200 kHz electric fields has been approved by the FDA. The device is made by Novocure. Here is the company's press release announcing the news. And here is a link to a story about the the device, we ran in Microwave News close to four years ago.

An essential part of the Interphone story is Appendix 2. Although not included in the paper, it offers a way to look at the risks free of some of the bias that so muddled the published results. It also provides a window on the controversy that deadlocked the Interphone group for four years.

There is a general consensus that the large number of abnormally low risks observed in Interphone is a sign of a systematic problem —selection bias— in the way that the study was carried out. As the Interphone group acknowledges, it is “unlikely” that cell phones could immediately provide protection against brain tumors (see main Interphone Story).

Pity those who are trying to follow the cell phone–brain tumor story. Their sense of the cancer risk is most likely a reflection of the last thing they read or saw on TV —It all depends on whose sound bite they happen to catch.

Take, for example, a paper published earlier this month in the Journal of the National Cancer Institute (JNCI) by a team of Scandinavian epidemiologists, under a rather bland title — “Time Trends in Brain Tumor Incidence Rates in Denmark, Finland, Norway and Sweden, 1974–2003.” But its message is anything but: Because there has been no increase in brain tumors between 1998 and 2003, a period when the use of cell phones “increased sharply,” cell phones are cancer safe.

Senator Arlen Specter (D-PA) will hold a hearing on cell phones and health on September 14. So says Devra Davis, an activist scientist at the University of Pittsburgh. If Specter follows through, it would be the centerpiece of a conference she is organizing that week in Washington, as well as a triumph for Davis herself. She is on a mission to make cell phones a more visible public health issue in the U.S. and to secure funding for a major research program. It would be the first time in more than 30 years that the U.S. Senate has addressed RF/microwave health risks.

Today's New York Times features a column by Tara Parker-Pope on cell phones and brain tumors, "Experts Revive Debate Over Cellphones and Cancer." As of this afternoon, it is the most popular story (most e-mailed) on the Times Web site.

It’s become axiomatic that wide acceptance of non-thermal effects will come from developing biomedical therapies rather than from studying potential hazards. The health effects work is mostly sponsored by those who don't want to find any. And they usually don't (cf: the USAF, EPRI, CTIA, FGF, MMF, etc.) So no one should be surprised that the latest advance comes from a small high-tech Israeli company, Novocure, which is looking for innovative ways to treat cancer. It's a breakthrough —most likely a major breakthrough.

Novocure uses weak 100-200 kHz electric fields —the company calls them tumor treating fields or TTFields— to stunt the growth of cancer cells, either by slowing down their proliferation or by killing them off entirely. The company has now demonstrated this in four different cancer cell lines. Even more impressive is that tumor growth has been curtailed in mice, rats and, in a small pilot project, ten human patients with recurrent brain tumors (glioblastoma).

The Karolinska group’s paper showing no increased risk of brain tumors among those who used a cell phone for ten or more years appears in the March 15 issue of the American Journal of Epidemiology. We first reported this result in December based on a brief announcement from Stockholm, but the published paper offers many more details.

One interesting item is the finding of a somewhat elevated risk of developing a glioma (a 60-80% increase) on the same side of the head as the phone was used. But, the Karolinska researchers also saw a lower than expected glioma risk on the opposite side of the head.